Seroquel (Quetiapine) Dosage
Seroquel
should commonly be administered with an initial dose of 25 mg, with
increases in increments of 25-50 mg. On the second and third day, to a dose
range of 300 to 400 mg daily by the fourth day. Further dosage adjustments,
should commonly occur at intervals of not less than 48 hours, as steady
state for Seroquel would not be achieved for approximately 1-2 days in the
typical patient. Most effective responses with Seroquel were obtained using
tid regimens, but in one controlled trial 225 mg bid was also effective.
Efficacy in schizophrenia was demonstrated in a dose of 150 to 750 mg/day in
the clinical researches supporting the effectiveness of Seroquel. In other
studies, however, doses of 400-500 mg/day appeared to be needed. The safety
of doses above 800 mg/day has not been evaluated in clinical researches, so
do not increase the dose yourself, but consult with your doctor. Dosing in
Special Populations Consideration should be given to a slower rate of dose
titration and a lower target dose in the elderly and in patients who are
debilitated or who have a predisposition to hypotensive reactions. When
indicated, dose escalation should be performed very careful in these
patients.
Patients with hepatic impairment should start with a 25 mg/day. The dose
should be increased by day in increments of 25-50 mg/day to an effective
dose, about increasing more please contact your doctor for further
instructions.
If something went wrong while taking or increasing the dose contact your
doctor immediately, he will do some researches and give proper information.
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